Fluid Retention Caused by Rosiglitazone Is Related to Increases in AQP2 and αENaC Membrane Expression

Figure 1

In vitro experiments on the cytotoxic effects of ROS, GW9662, SR1664, and TNFα in HEK293 and mIMCD-3 cells. (a) The effects of ROS, SR1664, and GW9662 (0.1, 1, and 10 μM) in HEK293 cells. (b) The effects of ROS, SR1664, and GW9662 (0.1, 1, and 10 μM) in mIMCD-3 cells. (c) The effects of TNFα (1, 5, and 10 ng/ml) in HEK293 and mIMCD-3 cells. (d) Coincubation with ROS (10 μM) and GW9662 (5 μM) and SR1664 (10 μM) and GW9662 (5 μM). The results show that the concentrations that we used in the experiments have no significant cytotoxic effects. Results are shown as mean ± s.e.m., .

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