Treatment of Diabetic Mice with a Combination of Ketogenic Diet and Aerobic Exercise via Modulations of PPARs Gene Programs

Figure 6

Aerobic exercise modulates PPARα and PPARγ gene programs in the mice liver. Gene expression of (a) PPARγ and (b)–(f) its target genes in mice livers from diabetic group, diabetes + KD and diabetes + KD + AE groups, after 6-week diet and exercise intervention. Gene expression of (h) PPARα and its target genes (g)–(j) in mice livers, from diabetic group, diabetes + KD and diabetes + KD + AE groups, after 6-week diet and exercise intervention. Gene expression of (k) FGF 21 and (l) GLUT2 is presented, after intervention. Results were examined by real-time PCR. Data were presented as means ± SEM ( per group) and statistical analysis was performed with 1-way ANOVA. versus diabetic group and versus diabetes + KD group.

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