Research Article

A Reduction in ADAM17 Expression Is Involved in the Protective Effect of the PPAR-α Activator Fenofibrate on Pressure Overload-Induced Cardiac Hypertrophy

Figure 1

Fenofibrate inhibited pressure-overload-induced cardiac hypertrophy in abdominal artery constriction- (AAC-) induced hypertensive rats. (a) HW/BW; (b) LVW/BW; (c) LVAW; (d) LVPW; (e) ANP mRNA level; (f) BNP mRNA level. Feno represents fenofibrate; HW/BW represents ratio between heart weight and body weight; LVW/BW represent ratio between left ventricular weight and body weight; LVAW represents left ventricular anterior wall thickness; LVPW represents left ventricular posterior wall thickness; #p<0.05 versus Sham group; p<0.05 versus AAC group, n=6 per group.
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