Effects of Dual Peroxisome Proliferator-Activated Receptors and Activation in Two Rat Models of Neuropathic Pain
Figure 1
Effects of i.p. injection of STZ on (a) blood glucose, (b) body weight in grams, and (c) mechanical PWT. Two-way ANOVA revealed the following results: (a) significant main effect of treatment [F(1,11)=20.46; p<0.0001], significant main effect of time [F(8,88)=6.535; p<0.0001], and significant main treatment X time interaction [F(8,88)=6.988; p<0.0001]. (b) Significant main effect of treatment [F(1,11)=9.151; p<0.05], no significant main effect of time [F(8,88)=0.9633; p=0.4669], and significant main treatment X time interaction [F(8,88)=5.027; p<0.0001]. (c) Significant main effect of treatment [F(1,11)=43.15; p<0.001], significant main effect of time [F(8,88)=4.289; p<0.01], and significant main treatment X time interaction [F(8,88)=2.864; p<0.001]. # indicates significant difference between groups. indicates significant difference versus week 0 (BL) within group. All data represent mean ± SEM of 6 rats. (PWT = paw withdrawal threshold in grams).