Effects of Dual Peroxisome Proliferator-Activated Receptors and Activation in Two Rat Models of Neuropathic Pain
Figure 3
Antinociceptive effects of tesaglitazar on cisplatin-induced neuropathic pain. (a) Effects of i.p. injection of cisplatin (accumulative dose of 23mg/kg) or vehicle on mechanical PWT. Two-way ANOVA revealed the following results: Significant main effect of treatment [F(1,10)=12.29; p<0.01], significant main effect of time [F(2,20)=12.02; p<0.001], and significant main treatment X time interaction [F(2,20)=6.269; p<0.01].# indicates significant difference between groups. indicates significant difference versus day 0 (BL) within group. (b) Effects of i.p. injection of tesaglitazar (20μg/kg) or vehicle on cisplatin-induced changes in PWT. Data are expressed as mean ± SEM of PWT in grams. Rats received i.p. injection of tesaglitazar (20μg/kg) or vehicle at the end of the cisplatin treatment cycles (day 21). Data are analyzed using Student's t-test (P<0.05, n=6 rats per group).