Short-Term Activation of Peroxisome Proliferator-Activated Receptors and Induces Tissue-Specific Effects on Lipid Metabolism and Fatty Acid Composition in Male Wistar Rats

Figure 3

Cardiac fatty acid composition (wt%) in Wistar rats after treatment with PPAR agonists for 12 days. Values are geometric mean (gSD). Red bars correspond to PPARα vs control and blue bars to PPARγ vs control. ANOVA, analysis of variance; MUFA, monounsaturated fatty acids; PPAR, peroxisome proliferator-activated receptor; PUFA, polyunsaturated fatty acids; SFA, saturated fatty acids. D5 desaturase index (n-6) = C20:4n-6 / C20:3n-6 (an indirect index of Δ5 desaturase activity based on n-6 PUFA). D5 desaturase index (n-3) = C20:5n-3 / C20:4n-3 (an indirect index of Δ5 desaturase activity based on n-3 PUFA). D6 desaturase index (n-6) = C18:3n-6 / C18:2n-6 (an indirect index of Δ6 desaturase activity based on n-6 PUFA). D6 desaturase index (n-3) = C18:4n-3 / C18:3n-3 (an indirect index of Δ6 desaturase activity based on n-3 PUFA). D9 desaturase index (C16) = C16:1n-7 / C16:0 (an indirect index of Δ9 desaturase activity based on C16 SFA/MUFA). D9 desaturase index (C18) = C18:1n-9 / C18:0 (an indirect index of Δ9 desaturase activity based on C18 SFA/MUFA). Anti-inflammatory index = ((C22:6n-3 + C22:5n-3 + C20:3n-6 + C20:5n-3) / C20:4n-6)100.