Diet Modifies Pioglitazone’s Influence on Hepatic PPARγ-Regulated Mitochondrial Gene Expression

Figure 7

Distinct effects of Pio vs other NHR agonists. (a, b) Venn diagrams depicting (a) distinct effects of PIO (reported here) versus obeticholic acid (Obe, reported in [45]) on the hepatic transcriptome in mice and (b) PIO (reported here) versus the LXRα agonist T0901317 (reported in [35]) on the liver RXR cistrome. (c) Hypothetical model illustrating how different NHR-binding drugs might exert unique effects on transcriptional regulation by competing for RXR-binding, with different NHR-RXR heterodimers displaying distinct affinities for specific NHR-RXR DNA response elements based on spacer length and other factors (e.g., RXR-ligand binding by 9-cis-retinoic acid). RXR homo-dimerization also affects transcription. The cell nucleus illustration is adapted from vectors from http://www.servier.com and licensed under the Creative Commons Attributions Unported license.

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