Role of PPARs in Progression of Anxiety: Literature Analysis and Signaling Pathways Reconstruction

Table 2

Anxiety-associated proteins and PPARs—directions of regulation.

Target	PPARA	PPARD	PPARG
BDNF	↑		↑
CREB1	↓		↓
CRP	↓		↓
FOS	↓		│
HSD11B2		↓
IFNG	↓	↓	↓
IL6	↓	↓	↓
LEP		↓	↓
NPY			↑
NR3C1	↓
PRL	↑
TNF	↓	↓	↓
TSPO	↓
VEGFA	↓	↑	↑

↑—positive regulation (increased expression), ↓—negative regulation (decreased expression), │—exact effect it unclear, empty field—interaction of this target gene with PPAR is unknown. Italics—decreased expression in anxiety, bold—increased expression in anxiety.