Role of PPARs in Progression of Anxiety: Literature Analysis and Signaling Pathways Reconstruction

Table 3

Top 10 for compound regulators subnetworks enriched for anxiety disorder-associated genes.

Gene Set Seed	Total number of neighbours	Overlap	Percent overlap	value	Jaccard similarity
Ginsenoside	106	11	10	1.97889-14	0.098214
Alpha-MSH	179	12	6	1.50466-13	0.065217
Epinephrine	292	13	4	1.50691-12	0.043919
Corticosterone	510	15	2	2.00908-12	0.029297
Norepinephrine	412	14	3	3.86353-12	0.033735
Li+	418	14	3	4.72452-12	0.033254
Serotonin	239	12	5	4.9582-12	0.04918
n-3 Polyunsaturated fatty acid	426	14	3	6.14958-12	0.032634
Dehydroepiandrosterone	330	13	3	7.35581-12	0.038922

value was calculated using Fisher’s exact test. Enrichment analysis that does not include experimental values when calculating enrichment from a list. The Jaccard similarity index (Jaccard similarity coefficient) compares members for two sets to see which members are shared and which are distinct. It is a measure of similarity for the two sets of data, with a range from 0% to 100%.