Nonclassical Axis of the Renin-Angiotensin System and Neprilysin: Key Mediators That Underlie the Cardioprotective Effect of PPAR-Alpha Activation during Myocardial Ischemia in a Metabolic Syndrome Model

Figure 7

Fenofibrate treatment decreased the area at risk in myocardial infarcted rats. Representative images of TTC staining. Blue areas indicate viable tissue; the red-colored region represents tissue at risk, and the white regions indicate the infarcted myocardium. CT-Sh and MetS-Sh: control and metabolic syndrome sham-operated groups; CT-MI-V: control myocardial infarction vehicle-treated; CT-MI-F: control myocardial infarction fenofibrate-treated; MetS-MI-V: metabolic syndrome myocardial infarction vehicle-treated; MetS-MI-F: metabolic syndrome myocardial infarction fenofibrate-treated.