Nonclassical Axis of the Renin-Angiotensin System and Neprilysin: Key Mediators That Underlie the Cardioprotective Effect of PPAR-Alpha Activation during Myocardial Ischemia in a Metabolic Syndrome Model

Table 1

The effects of fenofibrate administration on body characteristics and biochemical parameters from the control (CT) and MetS rats.

	CT-V	CT-F	MetS-V	MetS-F
Body weight (g)
Blood pressure (mmHg)			^a	^a
Intra-abdominal fat (g)			^a
Triglycerides (mg/dL)			^a	^b
HDL-C (mg/dL)			^a
Non-HDL-C (mg/dL)		^b	^a	^b
Total cholesterol (mg/dL)
Glucose (mg/dL)
Insulin (ng/mL)			^a	^b
HOMA-IR			^a	^b
CK activity (U/L)		^c	^a	^a,c

Values are . The serum biochemical determinations were performed after the myocardial insult. CT-V: control vehicle-treated; CT-F: control fenofibrate-treated; MetS-V: metabolic syndrome vehicle-treated; MetS-F: metabolic syndrome fenofibrate-treated; HOMA-IR: homeostatic model assessment of insulin resistance; HDL-C: high-density lipoprotein cholesterol; CK: creatine kinase. . ^a MetS vs. CT same treatment; ^b against vehicle corresponding group; ^c against vehicle corresponding group.