Peroxisome Proliferator-Activated Receptors as a Therapeutic Target in Asthma

Table 2

Proinflammatory lipid mediators and their functions.

Mediator		Function	Reference
LT family	LTC4	Bronchoconstriction	[101–104]
	LTD4	Bronchoconstriction
	LТЕ4	Bronchoconstriction
	LTF4	—
	LTA4	—
	LTB4	Mediates chemotaxis, plasma exudation, reduction of lung parenchyma
Prostanoid family	PGI2	Vasodilation, inhibitory effect on platelet aggregation	[43, 44, 92, 94, 105–107, 109, 110]
	PGE2	Bronchoconstriction, bronchodilation, activation of autonomic neurotransmitter pyrogenic hyperalgesia
	РGF2	Bronchoconstriction
	PGD2	Bronchoconstriction
	15d-PGJ2	Antioxidant effect
	TxA2	Vasoconstriction
Eoxin family	A4, C4, D4, E4	The development of allergy