miR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ

Figure 5

miR-22-3p suppressed the proliferation and migration of BC cells via PGC1β. (a–d) Knockdown of PGC1β partially reversed miR-22-3p inhibitor-induced promotion of proliferation in MDA-MB-231 and MCF-7 cells determined by MTT assay and colony assay. (e, f) Knockdown of PGC1β partially reversed miR-22-3p inhibitor-induced promotion of migration in MDA-MB-231 and MCF-7 cells determined by transwell assay. (g–i) Western blotting analysis for PGC1β/PPARγ protein level in MDA-MB-231 and MCF-7 cells. ; ; ; .

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