Fenofibrate Exerts Antitumor Effects in Colon Cancer via Regulation of DNMT1 and CDKN2A

<div>Fenofibrate administration inhibited colon cancer cell proliferation. (a) HCT116 and SW480 cells were treated with a range of concentrations of fenofibrate for 24 h. Cell viability was detected using CCK8. (b) EDU staining of cells was observed after incubation with fenofibrate for 24 h (magnification 200x). Box plot showing the statistics of fluorescence intensity. (c) Colony formation of cancer cells with or without fenofibrate treatment. (d) The PCNA immunofluorescence staining results of cells (magnification 200x). (e) The mRNA expression level of PCNA was measured following fenofibrate treatment. 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PPAR Research

fig2

Figure 2

Figure 2: Fenofibrate Exerts Antitumor Effects in Colon Cancer via Regulation of DNMT1 and CDKN2A 