Fenofibrate Exerts Antitumor Effects in Colon Cancer via Regulation of DNMT1 and CDKN2A

Figure 3

Fenofibrate treatment promoted colon cancer cell apoptosis. (a) Cell apoptosis was analyzed using flow cytometry. (b) TUNEL staining of colon cancer cells was observed after treatment of fenofibrate for 24 h. TUNEL-stained (green) cells indicate apoptosis-positive cells, DAPI (blue) indicates nucleated cells, and the merge column shows cells stained with TUNEL and DAPI. (c) Morphological changes were observed of HCT116 and SW480 cells after treatment of fenofibrate for 24 h. (d) The protein expression of Bax and Bcl-2 in SW480 and HCT116 cells was measured using western blot.

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