Inhibition of miR-128-3p Attenuated Doxorubicin-Triggered Acute Cardiac Injury in Mice by the Regulation of PPAR-γ

Figure 6

miR-128-3p targeted PPAR-γ in cardiomyocytes. (a) Binding site with miR-128-3p in 3-UTR of PPAR-γ. (b) The luciferase assay (). (c–f) The expression of miR-128-3p and PPAR-γ (). (g, h) The protein expression of PPAR-γ (). (i) p65-DNA binding activity (). (j) TNF-α mRNA level (). (k) ROS production in the cells (). (l) Cell viability (). (m) Western blot of Bax (). Data are expressed as . vs. matched control.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)

(k)

(l)

(m)