Buspirone Induces Weight Loss and Normalization of Blood Pressure via the Stimulation of PPARδ Dependent Energy Producing Pathway in Spontaneously Hypertensive Rats

Figure 3

Body weight, abdominal fat weight, triglyceride and HDL-cholesterol concentrations, and systolic and diastolic blood pressure levels in the serum of SHRs treated with buspirone 1, 5, or 10 mg/kg/day (0.01, 0.05, or 0.1 mg/mL/kg/day). Body weight and abdominal fat weight were decreased by the treatment buspirone 10 mg/kg/day (0.1 mg/mL/kg/day) compared to 8w untreated group (a and b). Triglyceride concentration was decreased in the groups treated with buspirone 5 and 10 mg/kg/day (0.05 and 0.1 mg/mL/kg/day) (c). HDL-cholesterol concentration was more elevated by buspirone 10 mg/kg/day (0.1 mg/mL/kg/day) than 8w (d). Systolic blood pressure increased at 8 weeks age SHRs was decreased in buspirone 5 and 10 mg/kg/day (0.05 and 0.1 mg/mL/kg/day) treated groups (e), and diastolic blood pressure level was lowered in buspirone 5- or 10 mg/kg/day (0.05- and 0.1 mg/ml/kg/day) treated group compared to 8w (f). The results are expressed as mean ± standard error of the mean (). Values were statistically analyzed using the unpaired t-test to compare two groups, and to compare means of three or more groups was used one-way ANOVA test and followed by Bonferroni’s multiple comparisons test. All experiments were repeated over three times. *, **, ***.

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