Buspirone Induces Weight Loss and Normalization of Blood Pressure via the Stimulation of PPARδ Dependent Energy Producing Pathway in Spontaneously Hypertensive Rats

Figure 8

In SHRs, buspirone ameliorates abnormal lipid metabolism and normalizes elevated abdominal fat mass, body weight, and biomarkers related to hypertension. Buspirone ameliorates abnormal lipid metabolism and elevated body weight through stimulating the pathway of PPARδ–AMPK–PGC-1α and normalizes blood pressure via the inhibition of AT1R and VCAM1. In addition, the effects of buspirone on skeletal muscle and abdominal fat can affect the modulation of hypertension. Meaning of symbols: arrow indicates activation and up, and horizontal line indicates inhibition.