Importance of Long-Acting Injectable Antipsychotic Preparation, Administration, and Injection Site Tolerability: A Focus on Paliperidone Palmitate Once-Every-6-Months Formulation

Figure 2

Plasma concentrations of PP formulations [17–19]. Note. PP1M, paliperidone palmitate once-monthly; PP3M, paliperidone palmitate once-every-3-months; PP6M, paliperidone palmitate once-every-6-months. Plasma concentrations represent deltoid injections for PP1M and PP3M. PP6M must be injected into the gluteal muscle only; it should not be administered by any other route [17–19]. Because of the difference in median pharmacokinetic profiles among PP1M, PP3M, and PP6M, caution should be exercised when making a direct comparison of their pharmacokinetic properties; correlation to clinical effect has not been established.