Research Article

Prevalence and Risk Factors for Opioid-Induced Constipation in an Older National Veteran Cohort

Table 2

Clinical characteristics of veterans covered by the study.

VariableVA + CMS count/percent

Outcomes
Constipation identification through diagnosis6,8724.49%
Constipation identification through procedure430.03%
Constipation identification through medication17,81011.65%

Medications
Laxative use prior year28,14318.41%
Constipating Meds-Prior Use from 1 year to 61 days9,0765.94%
Constipating Meds-Prior Use from 60 to 31 days3,4312.24%
Constipating Meds-Prior Use from 30 to 1 day132,30386.53%
Laxative use prior to opioid era32,59321.32%
Prevalent laxative9,4466.18%
Preventative laxative7,5144.91%

Medical conditions
Prior constipation diagnosis13,0718.55%
Prior constipation procedure440.03%
ImpactionLess than 110.00%
Hemorrhoids15,1609.91%
Gastrointestinal anatomical trauma5560.36%
Cerebrovascular disease19,25312.59%
Chronic kidney disease23,05115.08%
Colitis1,0330.68%
Congestive heart failure25,96016.98%
Coronary artery disease63,50941.54%
Diabetes mellitus60,62839.65%
Diabetic neuropathy5,6393.69%
Fibromyalgia4,0302.64%
Gastroparesis8990.59%
Hypercalcemia7500.49%
Hyperkalemia4,8383.16%
Hyperparathyroidism8520.56%
Hypertension126,93983.02%
Irritable bowel syndrome1,2360.81%
Megacolon570.04%
Migraine headache6,6374.34%
Multiple sclerosis3480.23%
Myocardial infarction5,1033.34%
Myopathies7,3964.84%
Osteoarthritis56,51436.96%
Parkinson’s disease3,5192.30%
Revascularization CABG18,57012.14%
Rheumatoid arthritis3,1662.07%
Stable angina13,5408.86%
Stroke11,1937.32%
Unstable angina17,95211.74%

Note. VA: Veterans Health Administration; CMS: Center for Medicare and Medicaid Services; CABG: coronary artery bypass grafting; “Constipating Meds-Prior Use” refers to the use of medications that have constipation as a side effect such as iron supplements.