Low Incidence of Postoperative Respiratory Depression with Oliceridine Compared to Morphine: A Retrospective Chart Analysis
Table 1
Demographic and baseline characteristics.
Characteristic
Oliceridine cohort (n = 213)
CO cohort (n = 225)
value
Female gender
125 (58.7)
112 (49.8)
0.076
Age, years, mean (SD)
62.6 (12.3)
60.1 (13.8)
0.039
<65 years
103 (48.4)
132 (58.7)
0.039
≥65 years
110 (51.6)
93 (41.3)
0.039
Race
White
159 (74.7)
181 (80.4)
0.180
Black/African American
47 (22.1)
37 (16.4)
0.170
Other
4 (1.9)
2 (0.9)
0.632
Unknown
3 (1.4)
5 (2.2)
ASA status
1
11 (5.2)
7 (3.1)
0.400
2
121 (56.8)
57 (25.3)
<0.0001
3
81 (38.0)
161 (71.6)
<0.0001
BMI, kg/m2, mean (SD)
31.2 (7.9)
31.5 (7.8)
0.689
<30 kg/m2
106 (49.8)
107 (47.6)
0.817
≥30 kg/m2
107 (50.2)
115 (51.1)
0.817
Surgery type
Bariatric
2 (0.9)
0 (0)
0.455
Colorectal
98 (46.0)
75 (33.3)
0.009
General
35 (16.4)
30 (13.3)
0.437
Orthopedic
78 (36.6)
120 (53.3)
0.0006
CORES (%)
175 (82.2)
176 (78.2)
0.362
COPD
38 (17.8)
42 (18.7)
0.920
Obesity
107 (50.2)
115 (51.1)
0.930
Renal impairment
10 (4.7)
5 (2.2)
0.246
Elderly
110 (51.6)
93 (41.3)
0.039
Sleep apnea
41 (19.3)
36 (16.0)
0.443
Opioid use 12 months prior to hospitalization
30 (14.1)
79 (35.1)
<0.0001
Information unknown
96 (45.1)
9 (4.0)
3 patients had missing BMI and excluded from the model; COPD = chronic obstructive pulmonary disease. Data are presented as n (%), except where specified. values were computed from t-test for age and BMI and from chi-square test for gender, age categories, race, ASA status, BMI categories, surgical type, and CORES status.
