Mannitol Enhances the Antinociceptive Effects of Diphenhydramine as an Alternative Local Anesthetic

Figure 4

Antinociceptive effects of diphenhydramine combined with epinephrine. The subcutaneous injection of 1% diphenhydramine with epinephrine solution (Epi, 1 : 100,000 dilution) did not increase antinociception compared with 1% diphenhydramine alone. However, the further addition of 0.5 M mannitol to the diphenhydramine and epinephrine solution significantly enhanced the antinociceptive effects. The values shown are the mean ± SEM, and there were seven animals in each group. , diphenhydramine with epinephrine and mannitol vs. diphenhydramine without the epinephrine and mannitol-treated group.