miR-223 Inhibits the Polarization and Recruitment of Macrophages via NLRP3/IL-1β Pathway to Meliorate Neuropathic Pain

Figure 1

Overexpression of miR-223 alleviates CCI-induced neuropathic pain and tissue damage. (a) miR-223 levels in the spinal cords of mice were measured by qRT-PCR at postoperative days 0, 3, 7, 14, and 21. n = 6 for each time point. compared to the sham group. (b) The expression of miR-223 in the spinal cords of CCI model mice infected with lentiviral vectors carrying miR-223 (Lenti-miR-223) or lentiviral vector (Lenti-vector) at postoperative day 7. n = 6 per group. compared to the sham group. compared to the CCI group. (c) The effect of miR-223 overexpression on thermal hyperalgesia was assessed by paw withdrawal thermal latency (PWTL). n = 6 per group. . (d) The effect of miR-223 upregulation on mechanical allodynia was evaluated according to the paw mechanical withdrawal threshold (PMWT). n = 6 per group. .

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