Effects of Curcumin Treatment in a Diabetic Neuropathic Pain Model of Rats: Involvement of c-Jun N-Terminal Kinase Located in the Astrocytes and Neurons of the Dorsal Root Ganglion

Figure 1

Simple experimental scheme. (a, b) Groups of rats were injected with saline solution at 0.9% intraperitoneally (IP). Four weeks later, they received either vehicle (Ctr + Veh), 10 mg/kg/day (Ctr + CMN10), or 50 mg/kg/day of curcumin (Ctr + CMN50) orally for 4 consecutive weeks. The experiments were subsequently conducted. (c, d) Groups of rats were injected with 50 mg/kg of streptozotocin (STZ) IP. Four weeks later, they received vehicle (STZ + Veh), curcumin 10 mg/kg/day (STZ + CMN10), or 50 mg/kg/day (STZ + CMN50) orally for 4 weeks before the start of the experiments.