| Study | Date | Country | Study design | Simple size | Migraine status | Treatment | Method | Score | Drug | Usage | Duration | Cost | Side effect |
| Cowan et al. [17] | 2016–2017 | American | Cross-sectional | 417 | ≥1 d/m | A new class of biologics | Subcutaneous injection | Administer monthly or quarterly | Disregarded | Unclear | Ranking | 9 | Mansfield et al. [18] | February and May, 2017 | American | Cross-sectional | 100 | ≥6 d/m | | Injection or oral pill | Once/m, once/d, twice/m | $5–$175/m | Yes | SG | 10 | Kol et al. [19] | 2008a | Netherlands | Cross-sectional | 151 | | Triptans, analgesics | | | | Yes | SG | 9 | Peres et al. [20] | 2007a | American | Cross-sectional | 250 | ≥12 m/y | β-blockers, calcium channel blockers, antidepressants, antiepileptics, neurotoxins | | Once/3 m, once/d, twice/d | Out-of-pocket expense | Yes | Ranking | 8 | Kelman [21] | 2006a | American | Prospective study | 1750 | | | | | | Yes | Interviews | 8 | Rozen [22] | 2006a | American | Cross-sectional | 150 | | Analgesic, natural therapy | | | | | Ranking | 9 | Wenzel et al. [23] | September to November, 2002 | American | Cross-sectional | 22 | | Over the counter | | Once/d | Low price | | Ranking | 9 | Lipton and Stewart [24] | 1998 | American | Cross-sectional | 688 | | | Capsule, subcutaneous injection | | | Yes | Interviews | 7 | Adelman et al. [25] | January to June, 1999 | American | Prospective study | 367 | | Rizatriptan | Disintegrating tablet, conventional tablet. | 10 mg/d, 6 m | | | Interviews | 8 | Pascual et al. [26] | 2001a | Spain | Case-control study | 94 | | Sumatriptan, zolmitriptan | Oral tablet | 50 mg, 2.5 mg | | | Ranking | 8 | Weidmann et al. [27] | 2003a | American | Case-control study | 33 | 2–6 d/m | Sumatriptan | Oral, intranasal, subcutaneous | | $45 | Yes | Ranking | 9 | Dahlöf et al. [28] | 2002–2003 | Sweden | Case-control study | 232 | Acute attacked | Zolmitriptan | Oral, intranasal, subcutaneous | 5 mg, 6 consecutive | | Yes | TTO | 9 | Lipton et al. [29] | 2005a | American | Cross-sectional | 415 | | Triptan | Oral | | | Yes | TTO | 8 | Schoenen et al. [30] | 2005a | American | Case-control study | 323 | Acute attacked | Eletriptan or sumatriptan | Oral, subcutaneous | 80 mg, 6 mg | | Yes | TTO | 8 | Lainez et al. [31] | 2001–2002 | Italy | Case-control study | 372 | Acute attacked | Rizatriptan, eletriptan | | 10 mg/40 mg | | | TTO | 9 | Dowson et al. [32] | 2007a | United Kingdom | Prospective study | 48 | 1–4 d/m | Zolmitriptan | Oral | 2.5 mg, 5 mg; 10 m | | | TTO | 8 | Diez et al. [33] | 2007a | Italy | Prospective study | 436 | 2–6 d/m | Rizatriptan, almotriptan | | 12.5 mg, 10 mg | | Yes | TTO | 9 | Lanteri et al. [34] | 2003 | France | Prospective study | 1710 | 6 d/1.5 m | Triptans, analgesics, ergot derivatives | | | | | Ranking | 9 | Bartolini et al. [35] | 2011a | Italy | Randomized controlled | 133 | 1–6 d/m | Frovatriptan, almotriptan | | 2.5 mg, 12.5 mg | | | Ranking | 10 | Gonzalez et al. [36] | 2013a | American | Cross-sectional | 510 | | | | | | | SG | 8 | Smelt et al. [37] | 2014a | Netherlands | Cross-sectional | 300 | | Triptans, ergotamine, analgesics | | | | | Ranking | 8 |
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