Methylprednisolone as an Adjunct to Local Infiltration on Laminoplasty or Laminectomy before Wound Closure: A Randomized Controlled Trial
Table 2
Comparison between primary outcomes and secondary outcomes among the MR (methylprednisolone plus ropivacaine) group and the R (ropivacaine) group in the first 48 hours postoperatively.
Time/variable
MR group (n = 66)
R group (n = 64)
value
Primary outcome
Cumulative sufentanil dose within 48 h (μg) SD
32.5 20.6
50.9 27.2
<0.001
Secondary outcomes
Cumulative sufentanil dose (μg)
0–4 h, SD
11.5 7.1
15.6 8.2
0.003
4–8 h, SD
9.8 5.6
14.6 7.4
<0.001
8–24 h, median (IQR)
6.0 (4.0, 10.0)
10.0 (8.0, 16.0)
<0.001
24–48 h, median (IQR)
4.0 (0, 6.5)
8.0 (4.0, 12.0)
<0.001
NRSM, median (IQR)
2 h
6.0 (5.0, 8.0)
7.0 (6.0, 9.0)
0.116
4 h
6.0 (5.0, 7.0)
7.0 (6.0, 9.0)
0.006
8 h
5.0 (4.2, 7.0)
7.0 (5.0, 8.0)
<0.001
24 h
4.0 (3.0, 5.2)
5.0 (4.0, 7.0)
0.005
48 h
3.0 (2.0, 5.0)
5.0 (3.0, 6.0)
0.003
3 days
2.0 (1.8, 4.0)
3.0 (2.2, 5.0)
0.001
1 week
0 (0, 1)
1 (0, 2)
0.024
2 weeks
0 (0, 0)
0 (0, 0)
0.034
4 weeks
0 (0, 0)
0 (0, 0)
0.983
NRSR, median (IQR)
2 h
3.0 (1.0, 4.0)
4.0 (2.2, 6.0)
0.007
4 h
2.5 (1.8, 4.0)
4.0 (2.0, 5.0)
0.001
8 h
2.0 (1.0, 3.0)
3.0 (2.2, 5.0)
<0.001
24 h
1.0 (0, 2.0)
2.0 (1.0, 3.0)
<0.001
48 h
0.5 (0, 1.0)
2.0 (1.0, 3.0)
<0.001
3 days
0 (0, 1)
1.0 (0, 2.0)
<0.001
1 week
0 (0, 0)
0 (0, 0)
0.061
2 weeks
0 (0, 0)
0 (0, 0)
0.076
4 weeks
0 (0, 0)
0 (0, 0)
0.983
PSS, median (IQR)
2 h
4.0 (3.0, 6.0)
4.0 (2.0, 5.0)
0.078
4 h
5.0 (4.0, 6.0)
4.0 (2.2, 5.0)
0.007
8 h
5.0 (5.0, 7.0)
5.0 (3.0, 6.0)
0.001
24 h
7.0 (5.0, 8.0)
5.0 (4.0, 7.0)
0.003
48 h
8.0 (6.0, 8.0)
7.0 (6.0, 8.0)
0.002
3 days
8.0 (7.0, 9.0)
8.0 (6.0, 8.0)
0.001
1 week
10.0 (9.0, 10.0)
9.0 (9.0, 9.0)
<0.001
2 weeks
10.0 (10.0, 10.0)
10.0 (10.0, 10.0)
0.220
4 weeks
10.0 (10.0, 10.0)
10.0 (10.0, 10.0)
0.325
Number of participants who did not receive oral rescue analgesic after the 48-hour postoperative period
18 (27.3%)
20 (31.3%)
0.618
Oral rescue analgesics received after the 48-hour postoperative period (tablets)
0 (0–3)
0 (0–3)
0.715
Note: oxycodone and acetaminophen tablets (Mallinckrodt Inc.), each tab containing 5 mg oxycodone hydrochloride (equivalent to 4.4815 mg) and 325 mg acetaminophen.
