Chronic Musculoskeletal Pain Moderates the Association between Sleep Quality and Dorsostriatal-Sensorimotor Resting State Functional Connectivity in Community-Dwelling Older Adults

Figure 1

Significant networks in the chronic pain-connectivity moderation analysis of the R2R rsFC when testing the PAIN_GROUP × PSQI interaction. Connections are represented by lines. The PAIN_GROUP × PSQI interaction was negative in all connections. The network formed by all eleven connections survived the TFNBS for the S-SP ROI configuration. The network formed by the blue solid and red connections survived the TFNBS for the SP-SP ROI configuration. The network formed by the red connections survived the TFNBS for the SP-A ROI configuration. The network formed by the solid red lines survived the TFNBS (marginally: left-tailed) for the S-A ROI configuration. The individual connection represented by the thicker red line was significant for all ROI configurations (, FDR corrected). The nodes of these networks are ROIs of the Harvard-Oxford AAL atlas. To clarify their anatomical extent, cortical ROIs are shown projected onto a semi-inflated white matter surface and subcortical ROIs are represented in the medial view of this surface. Pu = putamen. Cau = caudate. SMA = juxtapositional lobule cortex. PreCG = precentral gyrus. PostCG = postcentral gyrus.