Chronic Musculoskeletal Pain Moderates the Association between Sleep Quality and Dorsostriatal-Sensorimotor Resting State Functional Connectivity in Community-Dwelling Older Adults

Figure 2

Scatter plot of the rsFC values of the eleven connections that survived the TFNBS in the R2R connectivity analyses (when testing the PAIN_GROUP × PSQI interaction with the S-S ROI configuration) versus PSQI. The values of functional connectivity were adjusted by removing the demeaned residuals explained by age and sex. Thus, for each group (i.e., no-pain and chronic pain) the adjusted fitted rsFC lie in a straight line that represents the slope of the rsFC-PSQI dependency within the group. The negative PAIN_GROUP × PSQI interaction is explained by a change in slope from positive to negative when switching from the no-pain to the chronic pain group. For each connection, the Cohen’s f² local effect size index is shown, that is, the proportion of variance explained by the PAIN_GROUP × PSQI interaction divided by the residual variance. All effects were medium (0.15 ≤ f² < 0.35) or large (f² ≥ 0.35) [65]. Pu = putamen. Cau = caudate. SMA = juxtapositional lobule cortex. PreCG = precentral gyrus. PostCG = postcentral gyrus. R = right. L = left.