Research Article
CAV-1 Overexpression Exacerbates the Manifestation in EPAC-1-Induced Chronic Postsurgical Pain in Rats
Figure 8
Schematic diagram demonstrating the role of EPAC-1/CAV-1 in CPSP exacerbation. EPAC-1 and CAV-1 were overexpressed after surgery, particularly in astrocytes, microglia, and neurons of the spinal marrow. The overexpression of CAV-1 can induce the upregulation of CX43. And CAV-1 mediates the functional coupling of microglia, astrocytes, and neurons through the cAMP/EPAC-1 pathway. The EPAC-1 inhibitor CE3F4 and the EPAC-1 agonist 8-PCPT can help regulate the expression level of EPAC-1, thus affecting the CPSP exacerbation.