Positive Preemptive Analgesia Effectiveness of Pregabalin Combined with Celecoxib in Total Knee Arthroplasty: A Prospective Controlled Randomized Study

Table 3

hs-CRP level and knee functional indicator.

	Placebo (n = 36)	Celecoxib alone (n = 38)	Pregabalin alone (n = 38)	Combination (n = 37)	F	value
hs-CRP (ug/mL)
Preoperative	1.96 ± 0.47	2.08 ± 0.55	2.06 ± 0.45	2.17 ± 0.50	1.019	0.386
Postoperative 3 hours	23.05 ± 2.92	16.82 ± 3.16^a	24.62 ± 4.60^b	12.03 ± 1.73^abc	26.791	0.0002
Postoperative 24 hours	50.85 ± 4.60	32.46 ± 3.53^a	49.20 ± 5.37^b	23.93 ± 2.19^abc	33.442	0.0002
Postoperative 48 hours	108.43 ± 5.84	51.10 ± 3.52^a	101.30 ± 6.08^b	39.55 ± 2.89^abc	56.184	0.0001
ROM (degrees)
Postoperative 24 hours	46.65 ± 6.91	44.71 ± 7.63	43.49 ± 9.41	56.91 ± 5.21^abc	25.059	0.0002
Postoperative 48 hours	57.94 ± 8.43	58.58 ± 7.78	55.04 ± 8.89	70.12 ± 6.82^abc	25.896	0.0001
Postoperative 72 hours	61.27 ± 6.37	75.58 ± 7.77	73.90 ± 9.55	91.73 ± 7.77^abc	44.677	0.003
Time of first straight leg raise (hours)	21.83 ± 3.47	20.40 ± 2.04	20.14 ± 3.17	17.98 ± 2.09^abc	12.079	0.0003

hs-CRP, high-sensitivity C-reactive protein; ROM, knee range of motion. a means there was a significant difference compared with the placebo group (). b means there was a significant difference compared with the celecoxib group (). c means there was a significant difference compared with the pregabalin group ().