Positive Preemptive Analgesia Effectiveness of Pregabalin Combined with Celecoxib in Total Knee Arthroplasty: A Prospective Controlled Randomized Study
Table 4
Incidence of postoperative complications.
Placebo (n = 36)
Celecoxib alone (n = 38)
Pregabalin alone (n = 38)
Combination (n = 37)
χ2
value
PONV
8 (22.2%)
6 (15.8%)
5 (13.1%)
0 (0.00%)
8.483
0.034
Sedation score > 2
0 (0.00%)
0 (0.00%)
2 (5.26%)
2 (5.41%)
3.328
0.332
Dizziness
1 (2.78%)
1 (2.63%)
1 (2.63%)
2 (5.41%)
5.745
0.654
Urinary retention
1 (2.78%)
1 (5.26%)
4 (10.53%)
3 (8.11%)
1.216
0.876
Deep vein thrombosis
1 (2.78%)
1 (2.63%)
2 (5.26%)
0 (0.00%)
2.050
0.752
Gastrointestinal hemorrhage
0 (0.00%)
0 (0.00%)
0 (0.00%)
0 (0.00%)
—
—
Sedation was scored as 0 = no sedation; 1 = intermittent drowsiness; 2 = patient drowsy but arousable to verbal stimulus; and 3 = impossible to arouse verbally. PONV: postoperative nausea and vomiting; the difference was significant at the level.
