Research Article
Association of COMT Val158Met Polymorphism with Fibromyalgia in Khartoum State, Sudan
Table 1
COMT rs4680 Val158Met polymorphism and enzyme activity.
| | COMT gene polymorphism | Enzyme polymorphism | Enzyme activity |
| | HH | Val/Val | High (the H/H (Val-158-Val) genotype generates a fully effective enzyme) |
| | LH | Met/Val | Medium (the H/L (AG; Met-158-Val) genotype generates an intermediate-activity enzyme) |
| | LL | Met/Met | Low (the L/L (AA; Met-158-Met) genotype produces a defective enzyme, which impairs the clearance of catecholamines from the CNS) |
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