Soluble Epoxide Hydrolase Inhibitor TPPU Alleviates Nab-Paclitaxel-Induced Peripheral Neuropathic Pain via Suppressing NF-κB Signalling in the Spinal Cord of a Rat

Figure 5

sEH/NF-κB pathway-induced inflammatory factors and oxidative stress are involved in peripheral neuropathy induced by nab-paclitaxel. (a) Western blotting was used to detect the expression of sEH and NF-κB. (b) Effects of TPPU on the levels of inflammatory factors, including TNF-α, IL-1β, IL-6, IL-4, and IL-10, in the rat spinal cord were determined by ELISA. (c) Oxidative stress was present as the levels and activities of SOD, CAT, MDA, and GSH in the spinal cord. n = 6; compared to the control group, ^# compared to the nab-P group.

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