Research Article

Towards a Standard Psychometric Diagnostic Interview for Subjects at Ultra High Risk of Psychosis: CAARMS versus SIPS

Table 1

UHR criteria: similarities and differences between the SIPS 5.0 and the CAARMS 12/2006 (see also eTable 1 for details on the psychopathological dimensions investigated by P1–P5 and P1–P4).
(a) Rating system

SIPS version 5.0 [8]CAARMS version 12/2006 [16]

SubscalesP1: Unusual Thought Content/Delusional Ideas
P2: Suspiciousness/Persecutory Ideas
P3: Grandiose Ideas
P4: Perceptual Abnormalities/Hallucinations
P5: Disorganized Communication
P1: Unusual Thought Content
P2: Non-Bizarre Ideas
P3: Perceptual Abnormalities
P4: Disorganized Speech

Frequency1: at least several min per d at least 1/mo
2: several min/d at least once/wk in the past mo
3: at least 1 h/d for at least 4 d/wk over 1 mo
0: absent
1: less than 1/mo
2: 1/mo to 2/wk, <1 h per occasion
3: 1/mo to 2/wk, >1 h per occasion, OR 3 to 6/wk, <1 h per occasion
4: 3 to 6/wk, > 1 h per occasion, OR daily, <1 h per occasion
5: daily, >1 h per occasion, OR several times/d
6: continuous

Substance useExclusion criterion if strongly intertwined with symptoms0: no relation to substance use noted
1: occurs in relation to substance use and at other times as well
2: noted only in relation to substance use

Distress Subjective qualifier
Not used to determine an individual’s UHR status
Rated on scale 0–100
Not used to determine an individual’s UHR status

(b) Attenuated psychotic symptoms

Attenuated positive symptom psychosis-risk syndrome SIPS version 5.0 [8] Attenuated psychosis group
CAARMS version 12/2006 [16]

Inclusion criteriaSeverity score of 3–5 on at least one of P1–P5
PLUS
Frequency score of 2 on P1, P2, P3, P4, and/or P5
Subthreshold intensity
Severity score of 3–5 on P1, 3–5 on P2, 3-4 on P3, and/or 4-5 on P4
PLUS
Frequency score of 3–6 on P1, P2, P3, and/or P4
Subthreshold frequency
Severity score of 6 on at least one of P1, P2, and P4 and/or 5-6 on P3
PLUS
Frequency score of 3 on P1, P2, P3, and/or P4

OnsetSymptoms should have begun within the past year OR currently rate one or more scale points higher compared to 12 months before
Symptoms that occurred over the past month only are rated
Symptoms should have been present in the previous 12 mo AND for not longer than 5 y

Level of functioningNo social/occupational dysfunction requirement30% drop in SOFAS score from premorbid level, sustained for a mo, within the past 12 mo OR SOFAS score <50 for the past 12 mo or more

Exclusion criteriaSymptoms are strongly intertwined temporally with substance use episodes (substance-induced psychosis may be considered)Symptoms occur only during peak intoxication from a substance known to be associated with psychotic experiences (e.g., hallucinogens, amphetamines, and cocaine)
Symptoms are better accounted for by another DSM diagnosis
Past psychosis ruled in according to information obtained through the initial screen and evaluated using the POPS The person has had a previous psychotic episode (treated or untreated)

(c) Brief limited intermittent psychotic symptoms

Brief intermittent psychotic symptom psychosis-risk syndrome SIPS version 5.0 [8]Brief limited intermittent psychotic symptoms group
CAARMS version 12/2006 [16]

Inclusion criteriaSeverity score of 6 on at least one of P1–P5
PLUS
Frequency score of 1 on P1, P2, P3, P4, and/or P5
Severity score of 6 on at least one of P1, P2, and P4 and/or 5-6 on P3
PLUS
Frequency score of 4–6 on P1, P2, P3, and/or P4

OnsetSymptoms should have reached a psychotic level of intensity in the previous 3 moSymptoms should have been present in the previous 12 mo and for not longer than 5 y

Duration Up to 3 moUp to 7 d

Level of functioningNo social/occupational dysfunction requirement30% drop in SOFAS score from premorbid level, sustained for a mo, within the past 12 mo OR SOFAS score <50 for the past 12 mo or more

Exclusion criteriaSymptoms are strongly intertwined temporally with substance use episodes (substance-induced psychosis may be considered)Symptoms occur only during peak intoxication from a substance known to be associated with psychotic experiences (e.g., hallucinogens, amphetamines, and cocaine)
Symptoms are better accounted for by another DSM diagnosis
Past psychosis ruled in according to information obtained through the initial screen and evaluated using the POPS The person has had a previous psychotic episode (treated or untreated)
Symptoms are seriously disorganizing and dangerous
Symptoms do not resolve spontaneously (without antipsychotic medication)

(d) Genetic risk and deterioration syndrome

Genetic risk and deterioration psychosis-risk syndrome
SIPS version 5.0 [8]
Vulnerability group
CAARMS version 12/2006 [16]

Inclusion criteriaThe patient meets criteria for Schizotypal Personality Disorder
OR
The patient has a first-degree relative with a psychotic disorder
Schizotypal Personality Disorder in identified patient
OR
Family history of psychosis in a first-degree relative

Level of functioning30% drop in GAF score over the last mo as compared to 12 mo before30% drop in SOFAS score from premorbid level, sustained for a mo, within the past 12 mo OR SOFAS score <50 for the past 12 mo or more

CAARMS, Comprehensive Assessment of At-Risk Mental States; d, day; GAF, Global Assessment of Functioning; h, hour; min, minute; mo, month; SIPS, Structured Interview for Psychosis-Risk Syndrome; SOFAS, Social and Occupational Functioning Assessment Scale; UHR, ultra high risk; wk, week.