Chronic Traumatic Encephalopathy: A Review

Table 2

Areas of damage in the brain.

Gross areas of damage
(i) Reduced brain weight with atrophy of
Frontal lobe
Temporal lobe
Parietal lobe
Occipital lobe
(ii) Enlargement of lateral and third ventricles
(iii) Thinning of the corpus callosum
(iv) Cavum septum pellucidum with fenestrations
(v) Scarring and neuronal loss of cerebellar tonsils
(vi) Pallor of substantia nigra
Areas of tau NFTs and NT
(i) Superficial cortical layers
(ii) Dorsolateral frontal
(iii) Subcallosal
(iv) Insular
(v) Temporal
(vi) Dorsolateral parietal
(vii) Inferior occipital cortices
(viii) Thalamus
(ix) Hypothalamus
(x) Substantia nigra
(xi) Olfactory bulbs
(xii) Hippocampus
(xiii) Entorhinal cortex
(xiv) Amygdala
(xv) Brainstem