Multisite Kinetic Modeling of ¹³C Metabolic MR Using [1-¹³C]Pyruvate

Table 1

Exemplary parameter estimates (± standard error) obtained from three different kinetic modeling methods for a 40 mM (0.2 mmol/kg) dose of kidney predominant tissue.

Model	MSIM	2SIM	2SDM
[s^−1]
[s^−1]
[s^−1]
[s]
[s]
[s]
[s]			N/A^*

According to (1), 2SDM only fits for exchange rates and the corresponding values.