Research Article

Predicting Molecular Subtypes of Breast Cancer with Mammography and Ultrasound Findings: Introduction of Sono-Mammometry Score

Table 2

Demographic and histopathological characteristics.

Clinicoradiological features of breast cancersTotal (n = 313) (%)Luminal A (n = 62)Luminal B1 (Her-2-ve) (n = 71)Luminal B2 (Her-2+ve) (n = 47)TNBC (n = 77)Her-2–neu enrich (n = 56) value

Age
 20–3016 (5.1)1 (1.6)2 (2.8)2 (4.3)7 (9.1)4 (7.1)0.3
 30–50165 (52.7)33 (53.2)35 (49.3)30 (63.8)41 (53.2)26 (46.4)
 50–80132 (42.2)28 (45.2)34 (47.9)15 (31.9)29 (37.7)26 (46.4)

Side
 Right153 (48.9)32 (51.6)38 (53.5)20 (42.6)36 (46.8)27 (48.2)0.79
 Left160 (51.1)30 (48.4)33 (46.5)27 (57.4)41 (53.2)29 (51.8)

Mammography findings
 Negative7 (2.2)0 (0.0)2 (2.8)3 (6.4)1 (1.3)1 (1.8)0.232
 Positive306 (97.8)62 (100.0)69 (97.2)44 (93.6)76 (98.7)55 (98.2)

Ultrasound findings
 Negative2(0.6)0(0.0)0(0.0)0(0.0)0 (0.0)2 (3.6)0.05
 Positive311(99.4)62(100.0)71(100.0)47(100.0)77 (100.0)54 (96.4)

Focality
 Unifocal252 (80.5)48 (77.4)53 (74.6)37 (78.7)65 (84.4)49 (87.5)0.34
 Multifocal61 (19.5)14 (22.6)18 (25.4)10 (21.3)12 (15.6)7 (12.5)

T stage
 T02 (0.6)0 (0.0)0 (0.0)0 (0.0)0 (0.0)2 (3.6)0.06
 T130 (9.6)3 (4.8)8 (11.3)9 (19.1)4 (5.2)6 (10.7)
 T2112 (35.8)26 (41.9)31 (43.7)15 (31.9)27 (35.1)13 (23.2)
 T329 (9.3)6 (9.7)5 (7.0)3 (6.4)10 (13.0)5 (8.9)
 T4140 (44.7)27 (43.5)27 (38.0)20 (42.6)36 (46.8)30 (53.6)

N stage
 N093 (29.7)16 (25.8)23 (32.4)11 (23.4)26 (33.8)17 (30.4)0.81
 N1131 (41.9)27 (43.5)28 (39.4)22 (46.8)34 (44.2)20 (35.7)
 N289 (28.4)19 (30.6)20 (28.2)14 (29.8)17 (22.1)19 (33.9)

Histopathology
 IDC273 (87.2)47 (75.8)62 (87.3)44 (93.6)66 (85.7)54 (96.4)0.01
 ILC22 (7.0)7 (11.3)7 (9.9)3 (6.4)4 (5.2)1 (1.8)
 Metaplastic carcinoma10 (3.2)2 (3.2)0 (0.0)0 (0.0)7 (9.1)1 (1.8)
 Mucinous carcinoma4 (1.3)3 (4.8)1 (1.4)0 (0.0)0 (0.0)0 (0.0)
 Invasive papillary carcinoma3 (1.0)2 (3.2)1 (1.4)0 (0.0)0 (0.0)0 (0.0)
 Invasive carcinoma with neuroendocrine features1 (0.3)1 (1.6)0 (0.0)0 (0.0)0 (0.0)0 (0.0)

Grade
 I34 (10.9)14 (22.6)9 (12.7)5 (10.6)2 (2.6)4 (7.1)<0.01
 II193(61.7)36 (58.1)48 (67.6)28 (59.6)38 (49.4)43 (76.8)
 III86 (27.5)12 (19.4)14 (19.7)14 (29.8)37 (48.1)9 (16.1)

IDC: infiltrating ductal carcinoma, ILC: Infiltrating lobular carcinoma, TNBC: triple-negative breast cancer.