Research Article
Predicting Molecular Subtypes of Breast Cancer with Mammography and Ultrasound Findings: Introduction of Sono-Mammometry Score
Table 2
Demographic and histopathological characteristics.
| Clinicoradiological features of breast cancers | Total (n = 313) (%) | Luminal A (n = 62) | Luminal B1 (Her-2-ve) (n = 71) | Luminal B2 (Her-2+ve) (n = 47) | TNBC (n = 77) | Her-2–neu enrich (n = 56) | value |
| Age | 20–30 | 16 (5.1) | 1 (1.6) | 2 (2.8) | 2 (4.3) | 7 (9.1) | 4 (7.1) | 0.3 | 30–50 | 165 (52.7) | 33 (53.2) | 35 (49.3) | 30 (63.8) | 41 (53.2) | 26 (46.4) | 50–80 | 132 (42.2) | 28 (45.2) | 34 (47.9) | 15 (31.9) | 29 (37.7) | 26 (46.4) |
| Side | Right | 153 (48.9) | 32 (51.6) | 38 (53.5) | 20 (42.6) | 36 (46.8) | 27 (48.2) | 0.79 | Left | 160 (51.1) | 30 (48.4) | 33 (46.5) | 27 (57.4) | 41 (53.2) | 29 (51.8) |
| Mammography findings | Negative | 7 (2.2) | 0 (0.0) | 2 (2.8) | 3 (6.4) | 1 (1.3) | 1 (1.8) | 0.232 | Positive | 306 (97.8) | 62 (100.0) | 69 (97.2) | 44 (93.6) | 76 (98.7) | 55 (98.2) |
| Ultrasound findings | Negative | 2(0.6) | 0(0.0) | 0(0.0) | 0(0.0) | 0 (0.0) | 2 (3.6) | 0.05 | Positive | 311(99.4) | 62(100.0) | 71(100.0) | 47(100.0) | 77 (100.0) | 54 (96.4) | |
| Focality | Unifocal | 252 (80.5) | 48 (77.4) | 53 (74.6) | 37 (78.7) | 65 (84.4) | 49 (87.5) | 0.34 | Multifocal | 61 (19.5) | 14 (22.6) | 18 (25.4) | 10 (21.3) | 12 (15.6) | 7 (12.5) |
| T stage | T0 | 2 (0.6) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (3.6) | 0.06 | T1 | 30 (9.6) | 3 (4.8) | 8 (11.3) | 9 (19.1) | 4 (5.2) | 6 (10.7) | T2 | 112 (35.8) | 26 (41.9) | 31 (43.7) | 15 (31.9) | 27 (35.1) | 13 (23.2) | T3 | 29 (9.3) | 6 (9.7) | 5 (7.0) | 3 (6.4) | 10 (13.0) | 5 (8.9) | T4 | 140 (44.7) | 27 (43.5) | 27 (38.0) | 20 (42.6) | 36 (46.8) | 30 (53.6) |
| N stage | N0 | 93 (29.7) | 16 (25.8) | 23 (32.4) | 11 (23.4) | 26 (33.8) | 17 (30.4) | 0.81 | N1 | 131 (41.9) | 27 (43.5) | 28 (39.4) | 22 (46.8) | 34 (44.2) | 20 (35.7) | N2 | 89 (28.4) | 19 (30.6) | 20 (28.2) | 14 (29.8) | 17 (22.1) | 19 (33.9) |
| Histopathology | IDC | 273 (87.2) | 47 (75.8) | 62 (87.3) | 44 (93.6) | 66 (85.7) | 54 (96.4) | 0.01 | ILC | 22 (7.0) | 7 (11.3) | 7 (9.9) | 3 (6.4) | 4 (5.2) | 1 (1.8) | Metaplastic carcinoma | 10 (3.2) | 2 (3.2) | 0 (0.0) | 0 (0.0) | 7 (9.1) | 1 (1.8) | Mucinous carcinoma | 4 (1.3) | 3 (4.8) | 1 (1.4) | 0 (0.0) | 0 (0.0) | 0 (0.0) | Invasive papillary carcinoma | 3 (1.0) | 2 (3.2) | 1 (1.4) | 0 (0.0) | 0 (0.0) | 0 (0.0) | Invasive carcinoma with neuroendocrine features | 1 (0.3) | 1 (1.6) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| Grade | I | 34 (10.9) | 14 (22.6) | 9 (12.7) | 5 (10.6) | 2 (2.6) | 4 (7.1) | <0.01 | II | 193(61.7) | 36 (58.1) | 48 (67.6) | 28 (59.6) | 38 (49.4) | 43 (76.8) | III | 86 (27.5) | 12 (19.4) | 14 (19.7) | 14 (29.8) | 37 (48.1) | 9 (16.1) |
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IDC: infiltrating ductal carcinoma, ILC: Infiltrating lobular carcinoma, TNBC: triple-negative breast cancer. |