Research Article

Predicting Molecular Subtypes of Breast Cancer with Mammography and Ultrasound Findings: Introduction of Sono-Mammometry Score

Table 3

Ultrasound findings.

Imaging characteristicsTotal (n = 313)Luminal A (n = 62)Luminal B1 (n = 71)Luminal B2 (n = 47)TNBC (n = 77)Her-2 enrich (n = 56) value

Imaging findings
 Negative2 (0.6)0 (0.0)0 (0.0)0 (0.0)0 (0.0)2 (3.6)0.05
 Positive311 (99.4)62 (100)71 (100)47 (100)77 (100)54 (96.4)

Mass (n = 311)
 Shape
  Round5 (1.6)0 (0)0 (0)1 (2.1)4 (5.2)0 (0)<0.01
  Oval32 (10.2)4 (6.5)1 (1.4)1 (2.1)24 (31.2)2 (3.6)
  Irregular274 (87.5)58 (93.5)70 (98.6)45 (95.7)49 (63.6)52 (92.9)

Echogenicity
 Hypoechoic263 (84)51 (82.3)65 (91.5)42 (89.4)59 (76.6)46 (82.1)0.03
 Hyperechoic1 (0.3)0 (0)0 (0)1 (2.1)0 (0)0 (0)
 Isoechoic11 (3.5)4 (6.5)1 (1.4)1 (1.4)2 (2.6)2 (3.6)
 Complex36 (11.5)7 (11.3)5 (1.6)2 (4.3)16 (5.1)6 (10.7)

Margins
Well circumscribed15 (4.8)1 (1.6)0 (0)0(0)12(15.6)2(3.6)<0.01
Non-well circumscribed
 Microlobulated44 (14.1)5 (8.1)2 (2.8)7 (14.9)29 (37.7)1 (1.8)
 Irregular/spiculated252 (80.5)56 (90.3)69 (97.2)40 (85.1)36 (46.8)51 (91.1)

Orientation
 Parallel14 (4.5)4 (6.5)1 (1.4)1 (0.3)7 (2.2)1 (1.8)0.03
 Antiparallel297 (94.9)58 (93.5)70 (98.6)46 (97.9)70 (90.9)53(94.6)

Posterior features
 Enhancement only75 (24)7 (11.3)6 (8.5)3 (6.4)39 (50.6)20 (35.7)<0.01
 Shadowing only131 (41.9)34 (54.8)31 (43.7)16 (34.0)21 (27.3)29 (51.8)0.02
 Both present32 (10.2)5 (8.1)12 (16.9)8 (17)3 (3.9)4 (7.1)0.01
 Both absent73(23.3)16 (25.8)22 (31.0)20 (42.6)14 (18.2)1 (1.8)<0.01

Boundary
 Abrupt109(34.8)6 (9.7)15 (21.1)26 (55.3)41 (53.2)21 (37.5)<0.01
 Echogenic halo202(64.5)56 (90.3)56 (78.9)21 (44.7)36 (46.8)33 (58.9)

TNBC: triple-negative breast cancer.