Research Article
Predicting Molecular Subtypes of Breast Cancer with Mammography and Ultrasound Findings: Introduction of Sono-Mammometry Score
| Imaging characteristics | Total (n = 313) | Luminal A (n = 62) | Luminal B1 (n = 71) | Luminal B2 (n = 47) | TNBC (n = 77) | Her-2 enrich (n = 56) | value |
| Imaging findings | Negative | 2 (0.6) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (3.6) | 0.05 | Positive | 311 (99.4) | 62 (100) | 71 (100) | 47 (100) | 77 (100) | 54 (96.4) |
| Mass (n = 311) | Shape | Round | 5 (1.6) | 0 (0) | 0 (0) | 1 (2.1) | 4 (5.2) | 0 (0) | <0.01 | Oval | 32 (10.2) | 4 (6.5) | 1 (1.4) | 1 (2.1) | 24 (31.2) | 2 (3.6) | Irregular | 274 (87.5) | 58 (93.5) | 70 (98.6) | 45 (95.7) | 49 (63.6) | 52 (92.9) |
| Echogenicity | Hypoechoic | 263 (84) | 51 (82.3) | 65 (91.5) | 42 (89.4) | 59 (76.6) | 46 (82.1) | 0.03 | Hyperechoic | 1 (0.3) | 0 (0) | 0 (0) | 1 (2.1) | 0 (0) | 0 (0) | Isoechoic | 11 (3.5) | 4 (6.5) | 1 (1.4) | 1 (1.4) | 2 (2.6) | 2 (3.6) | Complex | 36 (11.5) | 7 (11.3) | 5 (1.6) | 2 (4.3) | 16 (5.1) | 6 (10.7) |
| Margins | Well circumscribed | 15 (4.8) | 1 (1.6) | 0 (0) | 0(0) | 12(15.6) | 2(3.6) | <0.01 | Non-well circumscribed | — | — | — | — | — | — | Microlobulated | 44 (14.1) | 5 (8.1) | 2 (2.8) | 7 (14.9) | 29 (37.7) | 1 (1.8) | Irregular/spiculated | 252 (80.5) | 56 (90.3) | 69 (97.2) | 40 (85.1) | 36 (46.8) | 51 (91.1) |
| Orientation | Parallel | 14 (4.5) | 4 (6.5) | 1 (1.4) | 1 (0.3) | 7 (2.2) | 1 (1.8) | 0.03 | Antiparallel | 297 (94.9) | 58 (93.5) | 70 (98.6) | 46 (97.9) | 70 (90.9) | 53(94.6) |
| Posterior features | Enhancement only | 75 (24) | 7 (11.3) | 6 (8.5) | 3 (6.4) | 39 (50.6) | 20 (35.7) | <0.01 | Shadowing only | 131 (41.9) | 34 (54.8) | 31 (43.7) | 16 (34.0) | 21 (27.3) | 29 (51.8) | 0.02 | Both present | 32 (10.2) | 5 (8.1) | 12 (16.9) | 8 (17) | 3 (3.9) | 4 (7.1) | 0.01 | Both absent | 73(23.3) | 16 (25.8) | 22 (31.0) | 20 (42.6) | 14 (18.2) | 1 (1.8) | <0.01 |
| Boundary | Abrupt | 109(34.8) | 6 (9.7) | 15 (21.1) | 26 (55.3) | 41 (53.2) | 21 (37.5) | <0.01 | Echogenic halo | 202(64.5) | 56 (90.3) | 56 (78.9) | 21 (44.7) | 36 (46.8) | 33 (58.9) |
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TNBC: triple-negative breast cancer. |