Clinical Features, Treatment, and Outcome in 102 Adult and Pediatric Patients with Localized High-Grade Synovial Sarcoma

Table 1

Patients and tumor characteristics.

Characteristic	Adult center (%)	Pediatric center (%)	Total (%)	P
Age				.0003
≤5 years	0 (0)	2 (13.3)	2 (2.0)
6–17 years	5 (5.7)	12 (80)	17 (16.7)
18–40 years	44 (50.6)	1 (6.7)	45 (44.1)
>40 years	38 (43.7)	0 (0)	38 (37.2)
Gender				.16
Female	42 (48.3)	4 (26.7)	46 (45)
Male	45 (51.7)	11 (73.3)	56 (55)
Tumour size				.5
<5 cm	31 (35.6)	4 (26.7)	35 (34.3)
≥5 cm	56 (64.4)	9 (60)	65 (63.7)
unknown	0	2 (13.3)	2 (2.0)
Depth				.69
Superficial	11 (12.6)	1 (6.7)	12 (11.8)
Deep	75 (86.2)	14 93.3)	89 (87.2)
Unknown	1 (1.1)	0 (0)	1 (1%)
Site				.0001
Upper extremity	26 (29.9)	2 (13.3)	28 (27.4)
Lower extremity	53 (60.1)	5 (33.3)	58 (56.9)
Pelvic	0 (0)	1 (6.7)	1 (1)
Shoulder	0 (0)	1 (6.7)	1 (1)
Other	8 (92)	6 (40)	14 (13.7)
Margins				.85
Negative	80 (92.0)	14 (93.3)	94 (92.2)
Microscopic  positive	7 (8.0)	1 (6.7)	8 (7.8)
Bone invasion				.2
Present	10 (11.5)	0 (0)	10 (9.8)
Absent	65 (74.7)	15 (100)	80 (78.4)
Unknown	12 (13.8)	0 (0)	12 (11.8)
Neurovascular Invasion				.58
Present	6 (6.9)	0 (0)	6 (5.9)
Absent	69 (79.3)	15 (100)	84 (82.3)
Unknown	12 (13.8)	0 (0)	12 (11.8)
Radiation therapy				.01
Yes	72 (82.8)	8 (53.3)	80 (78.4)
No	14 (16.1)	7 (46.7)	21 (20.6)
Unknown	1 (1.1)	0 (0)	1(1)
Chemotherapy				.0004
Yes	12 (13.8)	13 (86.7)	25 (24.5)
No	75 (86.2)	2 (13.3)	77 (75.5)