Stereotactic Body Radiotherapy for Metastatic and Recurrent Ewing Sarcoma and Osteosarcoma
Table 3
Description of palliative treatments.
Histology1
Patient age at time of SBRT (years)
Concurrent chemotherapy
Location
PTV size (cc)
SBRT total dose (Gy)
Fractions (number)
Pretreatment symptoms
Symptom relief2
Overall disease status (F/U, years)
Acute toxicity (grade)
Late toxicity (grade)
OGS
17.7
None
Scapula
54
21
1
Pain
Complete, durable
DOD (0.2)
None
N/A
OGS
17.7
None
C7-T1
34
24
3
None
N/A
DOD (0.2)
None
N/A
OGS
17.7
None
T4
17
24
3
Pain
Unclear
DOD (0.2)
None
N/A
OGS
5.1
None
T7–9
8.5
16
1
Pain
Complete, durable
DOD (0.04)
None
N/A
OGS
24.2
Topotecan and cyclophosphamide
Left lung
432
50
10
Pain
Partial, transient
DOD (0.8)
Esophagitis (2)
None
OGS
24.5
None
Mediastinum
127
50
10
Hemoptysis
Durable
DOD (0.5)
None
None
OGS
24.7
None
Left lung
67
40
5
Pain
Partial, transient
DOD (0.3)
Pain flare (2)
None
OGS
24.9
None
Zygoma
2.4
16
1
Pain
Complete, durable
DOD (0.1)
None
N/A
OGS
33.4
None
T8
10
40
5
None
N/A
AWD (1.2)
None
None
OGS
33.4
None
Ischium
9.6
40
5
None
N/A
AWD (1.2)
None
None
ES
28.7
None
Sacrum and left ilium
891
50
5
Pain
Complete, durable
DOD (0.1)
None
N/A
ES
28.7
None
C2
24
50
10
Pain
Complete, durable
DOD (0.1)
None
N/A
ES6
63.9
None
L2
3.9
25
5
Pain
Partial, transient
DOD (0.3)
None
None
Continguous similarly bolded/non-bolded rows denote multiple lesions in an individual patient.
1All patients had metastatic disease.
2Durable: until death or last follow-up.
3Intrathecal pain pump placed immediately after SBRT; pain relief ensued.
4Local failure noted at 0.6 years.
5Local failure noted at 0.1 years.
6Local failure noted at 0.2 years. PTV: planning target volume; SBRT: stereotactic body radiotherapy; OGS: osteosarcoma; DOD: dead of disease; ES: Ewing sarcoma; AWD: alive with disease.
