| | AE | Probability that AE is serious | Cost per AE, £ | Weighted average cost per AE, £ | | Pazopanib | Placebo | Nonserious | Serious | Pazopanib | Placebo |
| | General | | | | | | | | Alopecia | 100 | 0 | 0 | 0 | 0 | 0 | | Asthenia/fatigue | 15 | 17 | 122 | 122 | 122 | 122 | | Hypertension | 0 | 0 | 122 | 2,234 | 122 | 122 | | Myalgia/muscle pain | 40 | 0 | 122 | 122 | 122 | 122 | | Neurotoxicity/peripheral sensory neuropathy | 100 | 100 | 122 | 1,320 | 1,320 | 1,320 | | Edema | 0 | 0 | 122 | 1,602 | 122 | 122 | | Liver toxicity | | | | | | | | ALT elevation | 100 | 0 | 122 | 2,664 | 2,664 | 122 | | AST elevation | 100 | 100 | 122 | 2,664 | 2,664 | 2,664 | | Cardiovascular | | | | | | | | Cardiac toxicity | 100 | 0 | 122 | 3,843 | 3,843 | 122 | | Left ventricular dysfunction | 100 | 0 | 122 | 3,843 | 3,843 | 122 | | Pulmonary | | | | | | | | Dyspnea | 75 | 0 | 122 | 878 | 689 | 122 | | Pleural effusion | 0 | 0 | 122 | 1,974 | 122 | 122 | | Pneumothorax | 100 | 25 | 122 | 1,974 | 1,974 | 585 | | Pulmonary toxicity | 100 | 0 | 122 | 1,713 | 1,713 | 122 | | Gastrointestinal | | | | | | | | Decreased appetite/anorexia | 60 | 0 | 122 | 122 | 122 | 122 | | Diarrhea | 0 | 0 | 122 | 1,171 | 122 | 122 | | Nausea/vomiting | 7 | 0 | 122 | 1,171 | 195 | 122 | | Weight decreased | 9 | 0 | 122 | 122 | 122 | 122 | | Hematologic abnormalities | | | | | | | | Febrile neutropenia | 100 | 67 | 122 | 4,417 | 4,417 | 2,999 | | Anemia/hemoglobin | 0 | 0 | 122 | 1,482 | 122 | 122 | | Leucopenia | 0 | 0 | 122 | 4,417 | 122 | 122 | | Neutropenia/neutrophils | 100 | 100 | 122 | 4,417 | 4,417 | 4,417 | | Thrombocytopenia/low platelets | 50 | 50 | 122 | 2,051 | 1,086 | 1,086 |
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