Clinical Features and Outcomes Differ between Skeletal and Extraskeletal Osteosarcoma

Table 2

Univariate and multivariate prognostic factors for overall survival in a cohort of patients with extraskeletal osteosarcoma.

	Univariate hazard ratio; (95% confidence interval)	Univariate value	Multivariate hazard ratio; (95% confidence interval)	Multivariate value
Distant metastasis	3.16; (2.11–4.73)	<0.0001	2.39; (1.34–4.25)	0.003
Tumor size ≥10 cm	2.03; (1.40–2.95)	<0.0001	2.11; (1.41–3.17)	<0.0001
Axial tumor	1.98; (1.39–2.80)	<0.0001	1.65; (1.08–2.53)	0.021
Age; 18–32 years; 33–59 years; 60–99 years	Reference; 1.30 (0.63–2.70); 2.59 (1.31–5.12)	0.477; 0.006	Reference; 1.13 (0.45–2.79); 2.53 (1.08–5.90)	0.796; 0.032
Regional lymph node present	2.09; (1.14–3.83)	0.017	Not tested	Not tested
Male gender	1.32; (0.96–1.80)	0.086	Not tested	Not tested
Year of diagnosis; 1973–1979; 1980–1989; 1990–1999; 2000–2009	1.80 (0.87–3.75); 0.80 (0.44–1.45); 0.85 (0.59–1.23); Reference	0.115; 0.465; 0.390	Not tested	Not tested