Molecular Analysis of a Recurrent Sarcoma Identifies a Mutation in FAF1

Figure 3

Transcription factor activation. Nuclear extracts from tumor, muscle, and bone were tested for DNA binding activity on a protein-DNA array. (a) Transcription factor binding that was high in all 3 tissues and is therefore considered constitutively active is circled in yellow (left to right, top to bottom: AhR/Amt, GATA1, GATA2, GATA1/2, HIF1, and HOXD8/9/10). Transcription factors that show high binding in the cancer, but not in muscle or bone, are circled in red (left to right, top to bottom: E2F1, AP3, LIII-BP, PAX6, ADD-1, and CCAC). (b) The functions of transcription factors that display high DNA binding in the cancer, but not in muscle or bone, are described.

(a)

(b)