Radiation Therapy for Retroperitoneal Sarcomas: Influences of Histology, Grade, and Size

Table 1

Patient clinical and demographic characteristics categorized by receipt of perioperative radiation.

	Resection alone	Resection + radiation therapy
Median age (IQR)	61 [52–70]	59 [51–68]	0.002
Female sex	53.0%	53.2%	0.939
Race			0.034
Caucasian	84.4%	80.9%
African American	9.7%	13.3%
Others	5.9%	5.8%
Charlson-Deyo score			0.607
0	82.2%	83.2%
1	17.8%	16.8%
Facility type			<0.001
Nonacademic	31.5%	40.3%
Academic/research	62.9%	52.1%
Missing	5.6%	7.6%
Histology			<0.001
Liposarcoma	67.1%	46.4%
Leiomyosarcoma	21.5%	35.8%
Undifferentiated Pleomorphic
Sarcoma	2.0%	3.2%
Sarcoma, NOS	9.3%	14.7%
Operation			0.514
Simple/partial resection	28.5%	26.1%
Total resection	23.9%	25.7%
Debulking	4.9%	5.8%
Radical resection	42.6%	42.4%
Chemotherapy			<0.001
No chemotherapy	86.7%	79.8%
Chemotherapy	10.7%	16.9%
Missing	2.7%	3.3%
Median tumor size (IQR) (cm)	19.0 [12.0–29.0]	15.0 [9.0–20.6]	<0.001
Tumor size category			<0.001
<15 cm	36.8%	52.5%
>15 cm	63.2%	47.5%
Grade			<0.001
Low	48.8%	36.3%
High	40.3%	51.9%
Missing	10.9%	11.8%
Margin status			<0.001
Negative	52.6%	51.7%
Positive	32.1%	39.6%
Missing	15.3%	8.7%
30-day readmission (unplanned)	6.1%	5.0%	<0.001
Median hospital stay (days)	6	6	0.177
90-day mortality	4.3%	2.1%	0.013
Median OS (months)	82.7	95.8	<0.001
Interval survival (95% CI)
1 year	88.3%	92.7%
2 year	80.1%	84.2%
3 year	71.7%	74.9%
5 year	58.9%	61.6%
10 year	NR	4.0%