Correlation of High-Risk Soft Tissue Sarcoma Biomarker Expression Patterns with Outcome following Neoadjuvant Chemoradiation

Table 2

Correlation of posttreatment biopsy specimen tissue microarray biomarker expression with disease-free survival in 40 large, deep, high-risk soft tissue sarcoma patients treated with neoadjuvant chemoradiation.

Marker	HR (95% CI)	value
ACIS Ki67
Percentage	1.01 (0.60–1.68)	0.9813
p53
Nuclear/cytoplasmic ratio	4.13 (1.29–13.17)	0.0167
ATM
Nuclear	2.28 (0.34–15.32)	0.3971
Cytoplasm	1.86 (0.32–10.79)	0.4889
Tumor mask	1.33 (0.22–8.11)	0.7594
PARP1
Nuclear	1.38 (0.18–10.62)	0.7596
Cytoplasm	0.53 (0.12–2.33)	0.3982
Tumor mask	0.55 (0.13–2.42)	0.4317
ERCC1
Nuclear	0.77 (0.06–9.53)	0.8380
Cytoplasm	0.37 (0.11–1.21)	0.0991
Tumor mask	0.30 (0.09–0.97)	0.0443
XPF
Nuclear	0.01 (0.00–0.92)	0.0457
Cytoplasm	0.25 (0.03–2.35)	0.2271
Tumor mask	0.16 (0.02–1.62)	0.1207
CAIX
Nuclear	1.23 (0.48–3.13)	0.6713
Cytoplasm	1.33 (0.60–2.95)	0.4881
Tumor mask	1.32 (0.58–3.03)	0.5084
GLUT1
Nuclear	1.44 (0.50–4.18)	0.4989
Cytoplasm	1.24 (0.52–2.96)	0.6322
Tumor mask	1.26 (0.50–3.20)	0.6212
HIF-1α
Nuclear	0.59 (0.18–1.89)	0.3712
Cytoplasm	0.37 (0.12–1.16)	0.0885
Tumor mask	0.40 (0.14–1.17)	0.0945

HR: hazard ratio; CI: confidence interval.