Ifosfamide, Carboplatin, and Etoposide (ICE) in Combination with Regional Hyperthermia as Salvage Therapy in Patients with Locally Advanced Nonmetastatic and Metastatic Soft-Tissue Sarcoma
Table 6
Toxicity, according to the CTCAE 4.03 criteria, and dose reductions of ICE + RHT. Dose information was available for 106 patients (53 with locally advanced and 53 with metastatic disease).
Locally advanced disease (LA-STS, n = 54)
Metastatic disease (M-STS, n = 56)
Hematological toxicity
No. of patients (%)
No. of patients (%)
Grade III
11 (20.4)
13 (23.2)
Grade IV
25 (46.3)
20 (35.7)
Fever in cytopenia
15 (27.8)
12 (21.4)
Therapy-related deaths
3 (5.6)
0 (0.0)
ICE chemotherapy doses
Patients never receiving full dose
30 (55.6)
31 (55.4)
Further dose reductions needed (compared to dose of first applied cycle)
