Clinical Outcomes and Prognostic Factors for Patients with Malignant Peripheral Nerve Sheath Tumour

Table 3

Patient-, tumour-, and treatment-related characteristics and univariate analysis of prognostic factors for OS, LRFS, and MFS in 42 patients with nonmetastatic MPNST who underwent surgery of the primary tumour at our institutions.

Factors		N (%)	5-year OS (%)	value	5-year LRFS (%)	value	5-year MFS (%)	value
Age	≤50	20 (47.6)	71.7	0.522	83.9	0.294	72.1	0.665
	>50	22 (52.4)	90		73.2		68.3
Gender	Male	18 (42.9)	76	0.34	76.7	0.981	58	0.26
	Female	24 (57.1)	84.8		80.3		80.7
NF1 status	Present	21 (50)	79.1	0.531	73.7	0.73	58.6	0.067
	Absent	21 (50)	83.1		83.6		83.6
Location	Extremity	17 (40.5)	94.1	0.896	78.7	0.913	68.4	0.705
	Trunk	21 (50)	73.2		78.5		72.8
	Head and neck	4 (9.5)	75		75		75
Size	≤5 cm	19 (45.2)	87.7	0.389	87.5	0.576	82	0.233
	>5 cm	23 (54.8)	77.3		72.1		63.4
Depth	Superficial	16 (38.1)	84.4	0.644	80.8	0.836	71.4	0.992
	Deep	26 (61.9)	79.5		75.5		70.4
Grade	1	10 (23.8)	100	0.07	100	0.095	100	0.047
	2 or 3	32 (76.2)	76.4		72.1		62.5
Margin status	Negative	35 (80)	90.5	<0.001	86.5	<0.001	74	0.229
	Positive	7 (20)	35.7		38.1		47.6
N/A CT	Yes	11 (26.2)	78.7	0.692	80.8	0.621	77.9	0.818
	No	31 (73.8)	82.1		76.9		67.3
N/A RT	Yes	8 (19)	75	0.691	75	0.851	70	0.715
	No	34 (81)	82.6		78.4		69.9

OS, overall survival; LRFS, local recurrence-free survival; MFS, metastasis-free survival; MPNST, malignant peripheral nerve sheath tumour; NF1, neurofibromatosis Type 1; N/A CT, neoadjuvant and/or adjuvant chemotherapy; N/A RT, neoadjuvant and/or adjuvant radiotherapy.