Progressive Improvement in 5-Year Survival Rates for Extremity Soft Tissue Sarcomas from 1999 to 2019

Table 2

Univariate 5-year survival analysis stratified by time period.

Variable	1999–2005 (n = 1,393)		2006–2012 (n = 2,074)		2013–2019 (n = 2,187)
	Survival (%)		Survival (%)		Survival (%)
Demographics
Sex
Male	45	0.136	60	0.249	76	0.057
Female	50		62		79
Age group (years)
<30	78	<0.001	72	<0.001	89	<0.001
30–59	62		73		84
≥60	25		48		71
Race
Caucasian	47	0.342	62	0.257	78	0.173
African American	43		57		72
Other	48		59		79
Unknown	88		86		83
Ethnicity
Non-Hispanic	46	0.008	60	0.056	77	0.126
Hispanic	58		67		81
Marital status
Married	49	<0.001	65	<0.001	81	<0.001
Single	55		62		79
Other	32		46		64
Unknown	67		62		82
Tumor characteristics
Primary site
Upper extremity	54	0.151	61	0.185	76	0.226
Lower extremity	45		61		78
Size (cm)
<5	60	<0.001	73	<0.001	89	<0.001
5–10	47		60		79
>10	37		52.2		68
Grade
I	65	<0.001	87	<0.001	93	<0.001
II	61		74		86
III	36		47		68
Metastasis
No	53	<0.001	68	<0.001	82	<0.001
Yes	33		43		49
Histology
Fibromatous	41	<0.001	60	<0.001	81	<0.001
Myxomatous	46		69		81
Lipomatous	60		78		89
Myomatous	43		53		72
Synovial	54		62		81
NOS	38		44		58
All other types	38		47		70
Treatments
Surgery
No	21	<0.001	14	<0.001	35	<0.001
Yes	48		63		81
Radiation
No/unknown	48	0.731	65	0.005	78	0.333
Yes	47		58		77
Chemotherapy
No/unknown	49	0.011	66	<0.001	81	<0.001
Yes	40		45		62
Overall survival (%)	47		61		78

NOS, not otherwise specified; significant values are in bold.