Research Article

Randomized Controlled Trial of Clozapine and CBT for First-Episode Psychosis with Enduring Positive Symptoms: A Pilot Study

Table 2

Mean outcome measure scores at baseline and weeks 12 and 24 (as means and standard deviations). Missing values were provided using multiple imputation.

𝑁 BaselineWeek 12Week 24

BPRS-PTDZ11 1 0 . 4 ± 1 . 9 9 . 3 ± 2 . 5 9 . 4 ± 2 . 5
TDZ+CBT12 1 1 . 2 ± 2 . 7 8 . 0 ± 1 . 3 6 . 5 ± 1 . 8
CLZ14 1 1 . 8 ± 2 . 2 8 . 4 ± 3 . 1 8 . 7 ± 2 . 5
CLZ+CBT11 1 2 . 2 ± 2 . 8 9 . 1 ± 4 . 2 7 . 9 ± 4 . 0

SANSTDZ11 3 2 . 9 ± 1 3 . 0 2 8 . 4 ± 8 . 6 2 3 . 5 ± 7 . 2
TDZ+CBT12 3 7 . 2 ± 9 . 3 2 3 . 9 ± 5 . 1 2 5 . 9 ± 9 . 7
CLZ14 3 5 . 4 ± 1 1 . 8 2 9 . 4 ± 6 . 6 2 7 . 8 ± 8 . 0
CLZ+CBT11 4 0 . 2 ± 1 4 . 8 2 6 . 5 ± 1 2 . 1 2 4 . 9 ± 1 2 . 2

BDITDZ11 2 4 . 0 ± 6 . 5 2 2 . 9 ± 6 . 7 2 2 . 2 ± 6 . 7
TDZ+CBT12 2 9 . 0 ± 6 . 3 2 2 . 8 ± 4 . 4 1 7 . 0 ± 2 . 6
CLZ14 2 6 . 6 ± 8 . 1 1 8 . 1 ± 5 . 5 1 8 . 6 ± 4 . 9
CLZ+CBT11 2 5 . 2 ± 7 . 8 2 2 . 5 ± 9 . 6 2 2 . 6 ± 7 . 6

CGITDZ11 4 . 6 ± 0 . 5 3.6 ± 1.0 3 . 5 ± 0 . 8
TDZ+CBT12 4 . 8 ± 0 . 9 3.5 ± 0.8 3 . 0 ± 0 . 5
CLZ14 4 . 9 ± 0 . 7 3 . 6 ± 0 . 9 3 . 4 ± 0 . 8
CLZ+CBT11 4 . 8 ± 0 . 9 3 . 6 ± 1 . 4 3 . 5 ± 0 . 8

SOFASTDZ11 4 7 . 8 ± 1 2 . 6 53.2 ± 13.8 5 5 . 2 ± 1 2 . 3
TDZ+CBT12 4 3 . 0 ± 1 2 . 6 5 0 . 4 ± 9 . 2 5 5 . 4 ± 5 . 8
CLZ14 4 4 . 8 ± 9 . 9 5 4 . 0 ± 9 . 6 5 3 . 8 ± 9 . 8
CLZ+CBT11 4 5 . 2 ± 1 0 . 6 5 2 . 1 ± 1 1 . 1 5 5 . 4 ± 1 0 . 5

QLSTDZ11 4 8 . 7 ± 2 0 . 0 5 3 . 0 ± 1 7 . 2 5 9 . 6 ± 1 3 . 7
TDZ+CBT12 4 4 . 3 ± 1 4 . 2 4 9 . 8 ± 1 1 . 4 4 7 . 1 ± 1 3 . 1
CLZ14 5 0 . 2 ± 1 2 . 9 5 8 . 8 ± 1 0 . 4 5 4 . 5 ± 1 4 . 6
CLZ+CBT11 5 4 . 8 ± 1 5 . 7 5 9 . 3 ± 1 1 . 9 6 3 . 3 ± 1 6 . 1

Statistically significant, 𝑃 . 0 5 .