Abnormal Behaviors and Microstructural Changes in White Matter of Juvenile Mice Repeatedly Exposed to Amphetamine
Figure 4
AMP reduced the numbers of Nogo-A positive cells in cerebral cortex and corpus callosum. After treating with d-AMP or a same volume of saline for 21 days and subjected to behavioral tests, mice were sacrificed and their brains were processed for immunohistochemical staining. The numbers of Nogo-A positive cells in cerebral cortex and corpus callosum were counted. All AMP-treated mice had decreased Nogo-A cells than the average of CNT group. Representative photographs were presented and labeled. Quantitative data were statistically analyzed and presented in a bar chart. Data were expressed as means ± SEM. Comparisons were made between CNT and AMP groups. **.
